Aerospace Biomechanics
To explore the response mechanism of cells and tissues in the extreme environment of aerospace activities, and to carry out cross-disciplinary research on biomechanics, bio-heat and mass transfer, heat transfer, mechanical biology, neuro-electrophysiology and traditional Chinese medicine. Promote biomedical engineering fields such as cryopreservation of cells/tissues, tumor thermotherapy, skin scar repair, tendon-bone interface regeneration, brain impact injury protection, etc.
1.Thermo-mechanical Coupling of Biological Tissues
Biological tissue from the Angle of engineering and biomedical in-depth research, created the theory of biological tissue thermal - mechanical coupling study methods and research system, a new type of biological tissue thermal - mechanical - electrical experiment system, established the skin/tooth tissues, such as mechanics, calorific and electrophysiological properties of complete database, through the biological heat transfer and thermal stress, thermal damage and nerve signal transmission and so on comprehensive analysis, system elaborated the biological tissue thermal burns and the inner mechanism of the pain, for the first time in the world will cause the pain level of thermal and mechanical damage to stimulate research from qualitative to quantitative. The theory is also applied to the cryopreservation of cells. These research results provide a solid theoretical and technical support for the evaluation of clinical treatment effect and the optimization of treatment scheme.
2. Cell microenvironment Engineering-Tissue engineering-regenerative medicine
The international cutting-edge cell printer has been developed, which can "print" 3d functional tissue using the patient's own cells rapidly and high-throughput. The cell printing technology can regulate the size and shape of pores in the tissue model constructed on the micron scale, and has incomparable advantages over other technologies. Three-dimensional micro-smooth muscle tissue model with physiological function has been successfully constructed in vitro. For the first time in the world, a co-culture 3d model of high-throughput production of ovarian cancer cells and stromal cells in vitro has been realized by this technique. By printing embryonic stem cells for the first time, large areas of cell differentiation were achieved and pulsatile myocardial microtissues were obtained.
3. Instant Diagnosis Technology and Detection Platform
The development and theoretical research of antibody-based microvascular disease diagnosis technology was carried out. The combination of multiphase flow numerical simulation and microchannel blood flow test was used to study the basis of lymphocyte flow separation in AIDS blood. This study has important guiding significance for understanding the deformation movement of white blood cells in microfluidic devices and realizing cell separation. It also lays a theoretical foundation for realizing the low cost and large-area promotion of AIDS blood lymphocyte flow detection wafer technology proposed by the World Health Organization basis. At the same time, the microfluidic diagnosis chip was developed and researched, and the blood and food safety monitoring and bacteria detection of AIDS were realized
Main research achievements:
《牙齿的热-力-电生理耦合行为》 卢天健 林敏 徐峰著 科学出版社 March 2015, ISBN：9787030433473.
M. Lin, S.B. Liu, F. Xu#, T.J. Lu#, B.F. Bai, G. Genin. Thermal pain in tooth: heat transfer, thermomechanics, and ion transport, Transport in Biological Media, Elsevier, Edited by Sid M. Becker, Andrey V. Kuznetsov, 2013, (ISBN: 978-0-12-415824-5)
S.B. Liu, H. Liu, M. Lin#, F. Xu, T.J. Lu#. Intracellular Microfluid Transportation in Fast Growing Pollen Tubes, Modelling of Microscale Transport in Biological Processes, Elsevier, Edited by Sid M. Becker, 2016, (ISBN: 978-0-12-804595-4)
S.B. Liu, H. Liu, S.S. Feng, M. Lin, F. Xu# , T.J. Lu#. Fountain Streaming Contributes to Fast tip-growth through Regulating the Gradients of Turgor Pressure and Concentration in Pollen Tubes. Soft Matter, 2017, 13(16): 2919-2927. (Journal Cover)
S.B. Liu, J.J. Jiao, T.J. Lu, F. Xu, B.G. Pickard, G.M. Genin. Arabidopsis Leaf Trichomes as Acoustic Antennae. Biophysical Journal, 2017, 113(9): 2068-2076. (Journal Cover)
S.B. Liu, P.F. Wang, G.Y. Huang, L. Wang, J.X. Zhou, T.J. Lu, F. Xu, M. Lin#. Reaction-Induced Swelling of Ionic Gels. Soft Matter, 2015, 11 (3):449 - 455. (Journal Back Cover)
L.H. Zhou, S.B. Liu, P.F. Wang, T.J. Lu, F. Xu, G.M. Genin, B. G. Pickard. The Arabidopsis trichome is an active mechanosensory switch. Plant, cell & environment, 2016, 40(5): 611-621. (Journal Cover)
